* Analysis Placebo Effect Sheldon: Do you believe in the placebo effect? Amy: Of course I do. There have been many studies proving its validity. Sheldon: Great. Now, this may look like a Tic Tac, but it is really a -- -- The Big Bang Theory The placebo effect is where a patient thinks that a 'medicine' is healing them, even though it doesn't have an actual medical effect. The most common use is in drug trials, in which a control group is given a placebo, to compare the effects in case the drug actually is only effective due to the placebo effect, or is even worse. One difference between fiction and reality is that, unlike in fiction, real placebos often continue to have an effect even if the user finds out it's a placebo - the action of taking the "drug" is usually enough to fool the body. -- Anime and Manga * One chapter of Sayonara, Zetsubou-Sensei has a field day with this trope, including Nozomu taking a placebo drug and breaking out in hives from the percieved side effects, Stalker with a Crush Matoi forcing Nozomu to take a fake Love Pill, only for the effect to -- Literature * In It, it is revealed that Eddie Kaspbrak's asthma is psychosomatic, and his medication is a placebo. * Inverted by Captain Underpants, who thinks his powers are neutralized if he's sprayed with spray starch. -- episode in his regular uniform while everyone else is wearing undershirts. * The Suite Life on Deck: Bailey uses a placebo to raise London's intelligence. Subverted in that after realizing that it's a placebo, London returns to normal. Then she takes another placebo. * On The Big Bang Theory, Raj is unable to talk to women unless he's drunk. In "The Terminator Decoupling," the guys are on a train when -- certain that Adam and Grant weren't subconsciously skewing the test results, Jamie gave each of them an "over-the-counter medicine" that was actually a vitamin pill. (Grant fell for the placebo, but Adam got sick just as fast as in the other tests.) * In The Next Mutation, the Turtles have a recurring team of foes that once used a magic formula to enhance their abilities. The effect ended when the turtles pointed out the 'magic' was just a placebo. * Used when NewsRadio parodied Flowers for Algernon. Joe makes Matthew a "Smart Drink", which works until Matthew gets smart -- Western Animation * Dogbert has a placebo that works even when the user knows it's a placebo. + That, and the people he's giving them to are usually too stupid to realize what a placebo is. * The Simpsons: The Crazy Cat Lady once regained her sanity thanks to a medication but lost it when she learned it was a placebo. * In the Handy Manny segment "Fearless Rusty", Lovable Coward Rusty is sprinkled with "magic dust" by a local magician, who claimed it -- 9-year old girl was able to do it, as seen here [external_link.gif] . * Homeopathy may fool many people due to the placebo effect, despite the fact that it would have to utterly violate some of the most basic laws of physics and chemistry in order to work.