near-death experiences, and much more! The Mysterious Placebo * -- One of the most significant but widely misunderstood phenomena is the placebo effect. Research shows that the placebo effect can be greater and is far more ubiquitous than commonly thought. -- One of the questions that skeptics are asked most persistently is to explain how acupuncture, homeopathy, faith healing, Qigong, and other treatments work. Skeptics often use the placebo effect-a response to the act of being treated, not to the treatment itself-as an answer, but usually to no avail. I believe that's because most people, both logical and fuzzy thinkers, don't truly understand what the placebo effect is. Spontaneous remission and the placebo effect, which are known as nonspecific effects, are significant phenomena that have great impact on consumers and health-care professionals. Recovery from illness, -- treatment just because the improvement followed the treatment. H. K. Beecher's seminal paper "The Powerful Placebo" (Beecher 1955) is among the most frequently cited and was undoubtedly responsible for the double-blind study design having been adopted as the universal standard. Beecher reported on twenty-six studies and arrived at an average placebo response rate of 32.5 percent. From this figure comes the often cited statement that a fixed fraction (one-third) of the population responds to placebos. But this is a myth. A recent paper (Roberts et al. 1993) concluded that "under conditions of heightened expectations, the power of nonspecific effects (placebos) far exceeds that commonly reported in the literature." -- without some level of nonspecific effects. A number of other myths are associated with placebos. Try to answer the following questions: 1. Does a positive response to a placebo mean the patient's problem is imaginary? 2. Does a patient have to believe in the therapy for a placebo effect to occur? 3. Are placebos harmless? The answer to all three questions is no. Placebo responses can occur in patients with real disorders; the subjective symptoms can resolve while the objective ones remain. Belief in the treatment only appears to explain a portion of the placebo effect (Jarvis 1990). It appears that belief, operant conditioning, and suggestibility all play important roles. In an interesting experiment, a man experienced pain and -- the power of suggestion. Contrary to popular belief, placebos can be harmful. Placebo responses can "teach" chronic illness by confirming and/or reinforcing the delusion of imagined disease (Jarvis 1990). Patients can become dependent on nonscientific practitioners who employ placebo therapies. Such patients may be led to believe they're suffering from imagined "reactive" hypoglycemia, nonexistent allergies and yeast infections, -- realities is an unacceptable version of the 'double-blind.'" The use of placebos can undermine the doctor-patient relationship by requiring deception on the part of the caregiver. Consumer advocate Stephen Barrett has explicit reservations concerning overreliance on the placebo effect in clinical practice: "I am against people being misled. The quack who relies on a placebo effect is also pretending he knows what he is doing-that he can tell what is wrong with you and that he has effective treatment for just about everything . . . he is -- need" (Barrett 1977). In addition, placebos "need not always be beneficial and may be frankly toxic: dermatitis medicamentosa and angioneurotic edema (allergic-type reactions) have resulted from placebo therapy. More subtle but equally important negative placebo effects must occur when the physician by virtue of a moment of inattention, a raised eyebrow, or a transient look of disgust, loses the trust of his patient" (Bourne 1991). -- * Barrett, S. 1977. Health frauds and quackery. FDA Consumer 11:12-17. * Beecher, H. K. 1955. The powerful placebo. JADA 159:1602-1606. * Bourne, H. 1991. Unrecognized therapeutic measures, including placebo. In Clinical Pharmacology, ed. by K. L. Melmon and H. F. Morrelli. New York: Macmillan. * Jarvis, W. T. 1990. Dubious dentistry: A dental continuing