Types » Placebo Effect Placebo Effect What is a placebo? A placebo (pluh-see-bow) is a substance or other kind of treatment that it’s not a medicine. The person getting a placebo does not know for sure that the treatment is not real. Sometimes the placebo is in the form of a “sugar pill,” but a placebo can also be an injection, a What is the placebo effect? Even though they do not act on the disease, placebos seem to affect how person’s symptoms as a result of getting a placebo is called the placebo effect. Usually the term “placebo effect” speaks to the helpful effects a placebo has in relieving symptoms. This effect usually lasts unpleasant effects that happen after getting a placebo are sometimes effects. This means that the person taking the placebo may experience that he or she is getting a strong medicine, the placebo may be thought to cause the side effects. The placebo does not cause any of these placebo helps change the symptoms, or change the way the person Some patients can have the placebo effect without getting a pill, shot, doing something else they believe will help. That type of placebo How are placebos used? Placebos may be used in clinical trials. Clinical trials are research people in the study may be given a placebo, while others get the new treatment being tested. The main reason to have a placebo group is to The placebo looks, tastes, or feels just like the actual treatment, so outcomes. The placebo control makes it possible to “blind” patients and People in a study that uses a placebo should always know that there’s a chance they could be getting a placebo. It’s not OK to give someone a placebo. Please see our document Informed Consent for more information Those who get placebos in medical studies serve an important role. the treatment being tested. The placebo group provides an important unless there’s a placebo group and those people get better too. On the also happen to people in the placebo group. How does the placebo effect work? convincing proof that the placebo effect is a real effect. But there are studies showing that the placebo effect is real. For example, scientists have recorded brain activity in response to placebo. Since many scientific tests have shown the placebo effect, it’s one way we Some scientific evidence suggests that the placebo effect may be partly Many think the placebo effect occurs because the patient believes in placebo, it doesn’t mean the person’s illness or symptoms were not hormones drop. Taking a placebo may change their perception — for What’s commonly called the placebo effect even plays a role in This suggests that past experiences also play into the placebo effect. In one study that looked at the placebo effect in pain relief, one days, both groups were given a placebo that looked like the real pain response when they were given a placebo later. Those who had not gotten they got the placebo, even though they were told that they would. This placebo effect. after a placebo, is still being studied. Researchers believe it may be not have viewed their efforts as placebos. But their healing powers may Because placebos often have an effect, even if the effect doesn’t last long, some people think that the placebo produced a cure. But placebos tumor shrinks, placebos have very little, if any, effect. Still, placebos clearly can help reduce certain symptoms such as pain, placebos were sometimes given by doctors out of frustration or doctors polled said that they used a placebo when they felt that it Sometimes if the placebo looks more real, the person may think it’s an some people, an injection may have a stronger placebo effect than a Some believe that placebos seem to work because many illnesses improve taking a placebo. Just as natural endorphins may relieve pain once they scene much as it would to something it actually sees. A placebo may may simply be a placebo effect. If the patient believes in the not a placebo effect. thought of as placebo effects, some short-term effects are affected by There’s still much to find out about the placebo effect and all the ways it may work. Researchers agree that the placebo effect cannot cure Other things that can add to or be confused for the placebo effect with the placebo effect. These are effects that can cause a study to report that a placebo (or even a treatment) had some effect when in Along with the placebo or nocebo effect, incidental events (unrelated effects that might have happened without the placebo) might also be linked to the placebo because of their timing. For example, a headache or rash that happens soon after taking a placebo could be caused by something else entirely, but the person might think the placebo caused start feeling better after taking a placebo, that improvement may be thought to be due to the placebo. to what’s thought of as the placebo effect. Even in serious conditions the effect of timing, noted above. A person who was taking a placebo that the placebo had some effect. And a self-limited illness that goes away completely on its own at such a time might have the placebo-taker know they’re getting placebos will know that their headache is not due Studies comparing placebo to no treatment found that patients were more in their comfort if they were on placebo. This was observed when the the clinical trial. This can affect outcomes for both the placebo and placebo, are more likely to leave the study before it’s over. This placebo/nocebo responses. J Neurosci. 2003;23(10):4315-4323. Boström H. Placebo—the forgotten drug. Scand J Work Environ Health. Colloca L, Benedetti F. Placebo analgesia induced by social Haour, F. Mechanisms of the placebo effect and of conditioning. Hróbjartsson A, Gøtzsche PC. Is the placebo powerless? Systematic review with 52 new randomized trials comparing placebo with no Hróbjartsson A, Gøtzsche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med. Kaptchuk TJ. The placebo effect in alternative medicine: Can the Kaptchuk TJ, Kelley JM, Conboy LA, et al. Components of placebo effect: Link J, Haggard R, Kelly K, Forrer D. Placebo/nocebo symptom reporting placebo analgesia and their clinical relevance. Pain. 2001;93(1):77-84. Wampold, BE, Minami T, Tierney SC , Baskin TW, Bhati, KS. The placebo is powerful: Estimating placebo effects in medicine and psychotherapy reward responding explain placebo-induced expectations and effects. Sherman R, Hickner J. Academic physicians use placebos in clinical Victoria (Australia) Better Health Channel. Placebo effect. Last www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Placebo_effect? Wager TD, Rilling JK, Smith EE, et al. Placebo-induced changes in fMRI